1.
Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life
Liu Q, Zhang N, Li Z, He H
Clinics (Sao Paulo, Brazil). 2021;76:e2355
Abstract
OBJECTIVES To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients. METHODS A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel. RESULTS The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05). CONCLUSION In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.
2.
Neuroprotective effects of erythropoietin in patients with carbon monoxide poisoning
Pang L, Bian M, Zang XX, Wu Y, Xu DH, Dong N, Wang ZH, Yan BL, Wang DW, Zhao HJ, et al
Journal of Biochemical & Molecular Toxicology. 2013;27((5):):266-71.
Abstract
The purpose of this study was to evaluate the efficacy of erythropoietin (EPO) for treating patients with carbon monoxide (CO) poisoning. We conducted a randomized, prospective study of 103 patients with CO poisoning in two groups: an EPO group (n = 54; patients received EPO) and a placebo group (n = 49; patients received normal saline). The study endpoints were the functional outcome at day 30 (the Barthel index and neurologic sequelae), National Institutes of Health Stroke Scale (NIHSS) score, and the levels of S-100. At 18 days, the NIHSS score improved significantly and S-100 levels significantly decreased in patients in the EPO group. At 30 days, patients in the EPO group had a superior Barthel index and fewer patients had delayed neurologic sequelae (DNS). This study demonstrated that early administration of EPO to patients with CO poisoning improved neurological outcomes and reduced the incidence of DNS. 2013 Wiley Periodicals, Inc.
3.
Comparison of curative effect of low flow rate plasma exchange combined with hemofiltration for treatment of liver failure Chinese
Yang YF, Huang P, Zhang N, Gai XD, Feng XN, Zhong YD, Wang LR, Yang YJ, Zhao W
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue [Chinese Critical Care Medicine/Zhongguo Weizhongbing Jijiuyixue]. 2009;21((2):):111-3.
Abstract
OBJECTIVE To investigate the effect of plasma exchange (PE) combined with hemofiltration (HF) on liver failure. METHODS Seventy-seven inpatients with liver failure admitted during January 2006 to August 2007 were randomly assigned to receive PE combined with HF (PE+HF group, 38 cases), or PE alone (PE group, 39 cases). Forty-one inpatients with liver failure who had not received artificial liver support treatment were assigned to serve as control group. The survival rates and biochemical parameters of three groups were compared. RESULTS There was no significant difference in biochemical parameters before treatment among three groups. Compared with pre-treatment values, albumin (Alb), cholinesterase (ChE) and prothrombin activity (PTA) of both PE group and PE+HF group were significantly increased after treatment, and total bilirubin (TBIL), alanine transaminase (ALT), aspartate transaminase (AST) of both PE group and PE+HF group were significantly decreased after treatment (P<0. 05 or P<0. 01). The survival rate of PE group, PE+HF group and control group was 48. 7% (19/39), 68. 4% (26/38), and 29. 3% (12/41) respectively. The survival rate of PE+HF group was significantly higher than that of control group (chi(2)=12. 11, P<0. 01). The rate of recovery of consciousness of patients with hepatic encephalopathy in PE+HF group was higher than that of PE group (42. 8% vs. 0, P<0. 05). Compared with PE alone, the result was better when it was combined with HF in correction of electrolyte disturbance and acid-base imbalance (19/23 vs. 0/21, P<0. 05). CONCLUSION Treatment of liver failure by PE combined with HF is safe and effective, and its efficacy is higher than PE alone.