1.
Long-term use of deferiprone enhances significantly the left ventricular ejection function in thalassemia major
Maggio A, Capra M, Cuccia L, Gagliardotto F, Rigano P, Calvaruso G,, et al.,
Blood. 2011;118((21):): Abstract No. 5302.
2.
Management of chronic childhood immune thrombocytopenic purpura: AIEOP consensus guidelines
De Mattia D, Del Vecchio GC, Russo G, De Santis A, Ramenghi U, Notarangelo L,, et al.,
Acta Haematologica. 2010;123((2):):96-109.
Abstract
Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.
3.
Decrease of mortality during deferiprone treatments: results from a large randomised cohort of thalassemia major patients under the auspices of the Italian Society for Thalassemia and Hemoglobinopathies
Maggio A, Vitrano A, Capra M, Cuccia L, Gagliardotto F, Filosa A,, et al.,
Blood. 2008;112((11):): Abstract No. 3885.
4.
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
Bennett CL, Silver SM, Djulbegovic B, Samaras AT, Blau CA, Gleason KJ,, et al.,
Jama. 2008;299((8):):914-24.
5.
A therapeutic platelet transfusion strategy without routine prophylactic tranfusion is feasible and safe and reduces platelet transfusion numbers significantly: preliminary analysis of a randomized study in patients after high dose chemotherapy and autologous peripheral blood stem cell transplantation
Wandt H, Wendelin K, Schaefer-Eckart K, Thalheimer M, Schubert MS, Conradi R,, et al.,
Blood. 2008;112((11):): Abstract No. 286.
6.
Plasma exchange and aspirin plus high versus standard dose steroids in idiopathic thrombocytopenic purpura (TTP): a prospective, randomized study by the Italian Group for PTT
Balduini CL, Luppi M, Laurenti L, Klersy C, Pieresca C, Quintini G,, et al.,
ISTH Congress. 2007;: Abstract No. P-S-273.
7.
Results from a phase 3, randomized, double-blind, placebo-controlled study of darbepoetin alfa for the treatment of anemia in cancer patients not receiving chemotherapy or radiotherapy
Glaspy JA, Smith RE, Aapro M, Ludwig H, Pinter T, Smakal M,, et al.,
Haematologica. 2007;92((Suppl 1):): Abstract No. 0377.
8.
Epoetin alfa vs standard of care decreases number of packed red blood cell transfusions in patients receiving hyper-CVAD for acute lymphocytic leukemia, lymphoblastic lymphoma, and Burkitts lymphoma
Cabanillas ME, Thomas DA, Kantarjian H, Mattiuzzi GN, Bekele BN,, et al.,
Blood. 2006;108((11):): Abstract No. 4477.
9.
Improved endothelial function with combined chelation therapy in thalassaemia major
Tanner MA, Galanello R, Dessi C, Agus A, Smith GC, Westwood MA,, et al.,
Blood. 2006;108((11):): Abstract No. 1770.
10.
ReFacto and Advate: a single-dose, randomized, two-period crossover pharmacokinetics study in patients with hemophilia A
Di Paola J, Smith M, Mannucci P, Kollmer C, Feingold J, Kessler C,, et al.,
Transfusion. 2006;46((9s):):11A.. Abstract No. S24-030F.