1.
Management of chronic childhood immune thrombocytopenic purpura: AIEOP consensus guidelines
De Mattia D, Del Vecchio GC, Russo G, De Santis A, Ramenghi U, Notarangelo L,, et al.,
Acta Haematologica. 2010;123((2):):96-109.
Abstract
Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.
2.
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
Bennett CL, Silver SM, Djulbegovic B, Samaras AT, Blau CA, Gleason KJ,, et al.,
Jama. 2008;299((8):):914-24.
3.
The use of aprotinin to reduce transfusion requirements in children undergoing cardiac surgery: a meta-analysis
Arnold DM, Fergusson DA, Chan AK, Cook RJ, Fraser GA, Lim W,, et al.,
Blood. 2004;104((11):):742a.. Abstract No. 2718.
4.
Use of intravenous immunoglobulin for treatment of neurological conditions: a systematic review
Hutton B, Fergusson D, Sharma M, Tinmouth A, Wilson K, Cameron B,, et al.,
Blood. 2004;104((11):):990a.. Abstract No. 3642.