Population
Children and adults with sickle cell disease (19 studies, 0 RCTs).
Intervention
Limited (C/c, E/e, K) or extended (C/c, E/e, K, Jka/b, Fya/b, +/-S/s) serologic matching.
Comparison
Standard ABO and RhD matching alone.
Outcome
This systematic reviewed included 16 cohort studies, 2 cross-sectional studies, and 1 decision tree model examining costs. Low-quality evidence from observational cohort studies supported that alloimmunization prevalence can be decreased by extending serological red blood cell antigen matching. Transfusion reactions were generally poorly and inconsistently reported. There was no evidence reporting the effect prophylactic genotypic matching has on alloimmunization, autoimmunization or transfusion reactions. There were no studies comparing prophylactic genotypic matching to serologic matching. High-quality evidence supporting clinical decision making regarding best transfusion practices was lacking.