High-risk outpatients with early COVID-19 (n= 416).
Convalescent plasma (CP), (n= 207).
Regular plasma (non-CP, n= 209).
Patients had a median age of 60 years old, and symptoms for 5 days. During the 28 days of follow-up, 28 patients were hospitalized and two died. The odds ratio (OR) for an improved disease severity score with CP was 0.86 (95% credible interval: 0.59-1.22). The OR was 0.58 (95% confidence interval: 0.33-1.02) for patients with ≤5 days of symptoms. The hazard ratio for hospital admission was 0.61 (95% confidence interval: 0.28-1.34). No difference was found in viral RNA excretion nor in the duration of symptoms.