Autologous platelet rich fibrin in the treatment of 3-wall intrabony defects in aggressive periodontitis - a randomized controlled clinical trial
Journal of Periodontology. 2017;:1-9.
BACKGROUND Platelet rich fibrin (PRF), has recently found its application in osseous regeneration. The aim of present study is to explore the efficacy of PRF in treatment of intrabony defects in aggressive periodontitis. MATERIAL AND METHODS 54 intrabony defects in 17 patients were treated either with autologous PRF with open flap debridement (OFD) or OFD alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect change were recorded at baseline and 9 months postoperatively. RESULTS Mean PD reduction and mean CAL gain was significantly greater in PRF as compared to control group. Furthermore, significantly greater percentage of mean bone defect change was found in the PRF group. CONCLUSIONS Within the limit of the present study, there was greater greater bone fill at sites treated with PRF with conventional OFD than conventional OFD alone.
Clinical and radiographic comparison of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in primary molars
Journal of the Indian Society of Pedodontics and Preventive Dentistry. 2017;35((4)):367-373.
AIM: This study aimed to evaluate and compare the Platelet-rich fibrin (PRF) and Mineral trioxide aggregate (MTA) as a pulpotomy agent in primary molars. MATERIAL AND METHODS In this study, 50 primary molars from 50 healthy children aged 5-9 years requiring pulpotomy were randomly allocated into two groups. In PRF group, after coronal pulp removal and hemostasis, remaining pulp tissue was covered with PRF preparation. In the MTA group, the pulp stumps were covered with MTA (Pro Root MTA-Root Canal Repair Material, Dentsply International Inc.) paste obtained by mixing MTA powder with sterile water at a 3:1 powder to water ratio. All teeth were restored with reinforced zinc oxide eugenol base and glass - ionomer cement. Stainless steel crowns were given in both groups 24 h after treatment. Clinical evaluation was undertaken at 1, 3, and 6 months intervals whereas radiographic evaluation of the treated teeth was carried out at the interval of 6 months. RESULTS By the end of 6 months, the overall success rate was 90% in PRF group and 92% in MTA Group. A statistically significant difference was observed between the groups at 6 months of follow-up (P < 0.05). The results were statistically nonsignificant between the groups (P > 0.05). CONCLUSION Radiographic and clinical outcome in PRF group could suggest it as an acceptable alternative in pulpotomy of primary teeth. PRF holds a promising future in the area of primary tooth vital pulp therapy.
Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial
Journal of Periodontal Research. 2013;48((5):):573-81.
BACKGROUND The treatment of molar furcation defects remains a considerable challenge in clinical practice. The identification of clinical measurements influential to treatment outcomes is critical to optimize the results of surgical periodontal therapy. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet-rich fibrin (PRF) and autologous platelet-rich plasma (PRP) in the treatment of mandibular degree II furcation defects in subjects with chronic periodontitis. MATERIAL AND METHODS Seventy-two mandibular degree II furcation defects were treated with either autologous PRF with open flap debridement (OFD; 24 defects) or autologous PRP with OFD (25), or OFD alone (23). Clinical and radiological parameters such as probing depth, relative vertical clinical attachment level and horizontal clinical attachment level along with gingival marginal level were recorded at baseline and 9mo postoperatively. RESULTS All clinical and radiographic parameters showed statistically significant improvement at both the test sites (PRF with OFD and PRP with OFD) compared to those with OFD alone. Relative vertical clinical attachment level gain was also greater in PRF (2.87+/-0.85mm) and PRP (2.71+/-1.04mm) sites as compared to control site (1.37+/-0.58mm), and relative horizontal clinical attachment level gain was statistically significantly greater in both PRF and PRP than in the control group. CONCLUSIONS The use of autologous PRF or PRP were both effective in the treatment of furcation defects with uneventful healing of sites. 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.