Patients with acute upper gastrointestinal bleeding bleeding (12 studies, n= 14,100).
Tranexamic acid (n= 7101).
Placebo (n= 6999).
No significant difference in mortality, rebleeding, need for surgery, need for transfusion, or thromboembolic events, between treatments was found. However, there was an increased risk of venous thromboembolic events with tranexamic acid.