COVID-19 outpatients enrolled in two multicenter trials: COnV-ert and CoV-Early (n= 797).
Convalescent plasma (n= 390).
Placebo (n= 392).
Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of convalescent plasma for improved disease severity scale was 0.936; OR for hospitalization or death was 0.919. The convalescent plasma effect on hospital admission or death was largest in patients with ≤5 days of symptoms (OR 0.658). Convalescent plasma did not decrease the time to full symptom resolution.