Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels

Indian Pediatr. 1997 Jan;34(1):20-5.
Abstract
OBJECTIVE:

To study the effect of exchange transfusion (ET) on the levels of immunoglobulins (Ig) and C3 in neonatal sepsis with sclerema.

DESIGN:

Randomized controlled trial in a referral neonatal unit of a teaching hospital.

SUBJECTS:

Consecutive culture positive septic neonates with sclerema were enrolled and were randomized to undergo ET (study group, n = 20) or no ET (controls, n = 20).

RESULTS:

Mortality was 50% in the study group and 95% in controls. Gram negative organisms accounted for 85% in study group and 90% in controls. IgG, IgA and IgM levels rose significantly while C3 levels did not show significant rise 12-24 hours after ET. Ig and C3 levels did not change significantly in the controls.

CONCLUSION:

ET with fresh whole blood in septicemic newborns with sclerema improves survival, particularly in the more premature group and significantly enhances, IgG, IgA and IgM levels.

Metadata
MESH HEADINGS: Bacteremia; Complement System Proteins; Exchange Transfusion, Whole Blood; Female; Humans; Immunoglobulins; Infant, Newborn; Infant, Premature; Male; Sclerema Neonatorum; Statistics, Nonparametric; Survival Rate
Study Details
Study Design: Randomised Controlled Trial
Language: English
Credits: Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine